منابع مشابه
The eukaryotic RNA exosome.
The eukaryotic RNA exosome is an essential multi-subunit ribonuclease complex that contributes to the degradation or processing of nearly every class of RNA in both the nucleus and cytoplasm. Its nine-subunit core shares structural similarity to phosphorolytic exoribonucleases such as bacterial PNPase. PNPase and the RNA exosome core feature a central channel that can accommodate single strande...
متن کاملRNA surveillance and the exosome.
Publisher Rights Statement: © 2015 Tollervey This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. Corresponding author: [email protected] Article and publication date are at http://www.rnajournal.org/cgi/doi/ 10.1261/rna.050989.115. Freely available online t...
متن کاملRNA channelling by the eukaryotic exosome.
The eukaryotic exosome is a key nuclease for the degradation, processing and quality control of a wide variety of RNAs. Here, we report electron microscopic reconstructions and pseudo-atomic models of the ten-subunit Saccharomyces cerevisiae exosome in the unbound and RNA-bound states. In the RNA-bound structures, extra density that is visible at the entry and exit sites of the exosome channel ...
متن کاملThe exosome: A versatile RNA processing machine
A conserved complex of multiple 3'-to-5' exonucleases has been discovered recently in eukaryotes. This essential complex, the exosome, is required for diverse RNA processing events.
متن کاملThe Exosome A Proteasome for RNA?
is presumably because defects in one exosome subunit The eukaryotic cell contains a wide variety of RNA specause a failure to assemble the exosome properly, and cies that are either processed from 39-extended precurthe exosome per se is required for viability. This conclusors or degraded in a 39-to-59 direction. How 39-to-59 sion is supported by the observations that inactivation processing is ...
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ژورنال
عنوان ژورنال: Cell
سال: 2019
ISSN: 0092-8674
DOI: 10.1016/j.cell.2019.09.005